Symbol
Name
ID

Gnb1
guanine nucleotide binding protein (G protein), beta 1
MGI:95781

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Delayed myelination

Polymicrogyria

Global brain atrophy

Cerebral palsy

Myoclonus

Hemiplegia

EEG with occipital slowing

EEG with temporal sharp slow waves

EEG with temporal focal spikes

Multifocal epileptiform discharges

EEG with generalized epileptiform discharges

EEG with burst suppression

Hypsarrhythmia

Phonic tics

Delayed speech and language development

Expressive language delay

Severe receptive language delay

Anxiety

Atypical behavior

Autism

Aggressive behavior

Motor tics

Attention deficit hyperactivity disorder

Intellectual disability

Hyperreflexia

Dystonia

Limb dystonia

Inability to walk

Developmental regression

Global developmental delay

Seizure

Bilateral tonic-clonic seizure

Focal impaired awareness seizure

Generalized non-motor (absence) seizure

Focal-onset seizure

Focal hemiclonic seizure

Generalized tonic seizure

Febrile seizure (within the age range of 3 months to 6 years)

Atonic seizure

Infantile spasms

Myoclonic seizure

Tonic seizure

Status epilepticus

Disease(s) Associated with GNB1

autosomal dominant intellectual developmental disorder 42

Mouse Phenotypes

minimal clonic seizures

abnormal spike wave discharge

abnormal neuron differentiation

abnormal neuronal precursor proliferation

abnormal neural plate morphology

abnormal embryonic neuroepithelium morphology

abnormal brain morphology

abnormal cortical ventricular zone morphology

decreased brain size

thin cerebral cortex

exencephaly

Availability

Mouse Genotype

Gnb1^{Gt(prvSStrap)4B8Yiw}/Gnb1^{Gt(prvSStrap)4B8Yiw}

Gnb1^em1Dgold/Gnb1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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